(Python3.6.1, Django==1.11.20, PyMySQL==0.9.3)
models.py
class HogeFile(models.Model): binary_file = models.BinaryField()
manage.py shell
$ python manage.py shell_plus >>> from pathlib import Path >>> file = Path('/Users/hoge/fuga.csv').read_bytes() >>> HogeFile.objects.create(binary_file=file) <HogeFile: HogeFile object>