(Python3.6.1, Django==1.11.20, PyMySQL==0.9.3)
models.py
class HogeFile(models.Model):
binary_file = models.BinaryField()
manage.py shell
$ python manage.py shell_plus
>>> from pathlib import Path
>>> file = Path('/Users/hoge/fuga.csv').read_bytes()
>>> HogeFile.objects.create(binary_file=file)
<HogeFile: HogeFile object>